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Generally, nothing inherently wrong with sending a username but directing people to a 3rd party social media platform rather than an official Anthropic email or support system does nothing to build trust that they actually work there.


This is a really interesting perspective. Thanks for sharing.

In your opinion, what would a product that successfully provides low cost computing in developing markets look like? Is one even needed?


I have to agree with this. The software was always serviceable before the new app. I have a Sonos speaker in my kids’ rooms that we often use for audiobooks and lullabies.

Even with the latest version of the new app, when I play something on both speakers, there is a delay from seconds up to a minute before sound comes through the second speaker, they play at wildly different random volumes each time, playing Audible books within the Sonos app no longer works, Airplay won’t connect about 30% of the time, and sometimes they just decide not to work at all for no apparent reason.

Every night I fight the urge to throw them in the bin. I’m contemplating replacing them but don’t know enough about alternatives yet.


And they provided an interesting tidbit of information about some of the units mentioned. I didn’t read it as anything negative towards your comment at all. Both your’s and their’s added to the conversation.


Oh, now you're just trolling the Apostrophe Nazis! ;)


I took their question to be shorthand for “Can you please share the image?”


Well no, if that’s the question. It’s the IP of the company I work for.


Or they’re looking for someone with a few of the listed skills.

I’d be totally on board with job ads saying “the team’s tech stack includes A-Z. No one is expected to be an expert in all of these but if you have experience with some of them or equivalent tech, we could be a good fit for each other.

Depending on circumstances, the ad could go on to say stuff like “we’d love to boost our capabilities in these particular skills” to call out anything that’s an area they want to focus on improving with the new hire, if there is one.


At my kids’ childcare, by far the most popular educator is non-binary. They do a great job of listening to the kids, and talking to them without talking down to them. Come to think of it, the way they interact with the kids actually reminds me a fair bit of the parents in Bluey.

Both my kids (3 and 5 but now at school) have said stuff like “Today we did x with Greg. He’s not exactly a boy and not exactly a girl.” Then they get on with their day. To them, it’s just another person that’s a bit different to them.


I guess this is more common in US then.

I live in a pretty liberal European city, yet I haven't met any non-binary person. I know exactly one trans person, and only remotely (she lives in US). I guess to me, this topic seems "advanced", perhaps "irrelevant" in a way for such a small kid. There are many other things she needs to learn about, which she will commonly experience in the real world.


> I live in a pretty liberal European city, yet I haven't met any non-binary person.

Being nonbinary is kinda unusual, but it's also probably something that's super easy to be closeted about, if you don't know how people will react.

I mean in the 1980s I thought all 900 kids in my high school were straight, and that being gay was super uncommon.


80s in California... there was a sizable but not exactly large group. No one cared. We all knew "old people" were supposed to care, but it was more likely just a thing everyone had to pretend to care about on TV. None of the old people I knew cared either.

Future "not evenly distributed" and all that.


Depends on the circle. Tech industry in California, know 2 NBs, and 2 trans people (and then 2 more I knew transitioned after I left work and contact with them). I guess that does fit all the liberal stereotypes that people like to throw at my State.


I'm in London, and I've met a few non-binary people (enbys), and had at least two trans people in my school (one student, one teaching assistant; this was in the mid-2000s).


> the ones for the CV vaccine were listed on many pages of tiny text (both from Pfizer and from Moderna)

The size of the pages side effects were written on says absolutely nothing about what the side effects are or their severity.

> Then there are the long term consequences, many studies keep coming out with surprises (recent buzzword “Ribosomal frameshift”

Ribosomal frameshift is in itself not a “long term consequence.” It is simply that depending on where translational of a piece of mRNA starts, different proteins can be produced. This is an essential part of how our own (or any other organism’s mRNA) is translated into proteins. other proteins present in a cell can regulate which proteins can be produced - again an essential part of how our cells function. This has been known about for decades.

It is one of the main potential areas that could lead to side effects of an mRNA vaccine so understanding what other proteins might be translated and under what circumstances is important.

Please don’t fear monger without any actual evidence to back it.


I think the methylated pseudouridine is actually a tRNA component. Could be wrong. I’m not sure what the 3D structure of the vaccine mRNA is, but it could depart quite a bit from the high-school-biology linear strand portrayal of mRNA.

> other proteins present in a cell can regulate which proteins can be produced - again an essential part of how our cells function

I thought manipulating this was a design goal.

Regardless, I somewhat doubt the simple story presented to the public is 100% accurate.


> The size of the pages side effects were written on says absolutely nothing about what the side effects are or their severity.

Naive question: Do they say what the side effects are and their severity in an easily accessible manner somewhere?


The official package insert can be read here: https://www.drugs.com/pro/moderna-covid-19-vaccine.html


From the sibling comment link I would say, yes:

5 WARNINGS AND PRECAUTIONS

5.1 Management of Acute Allergic Reactions

Appropriate medical treatment to manage immediate allergic reactions must be immediately available in the event an acute anaphylactic reaction occurs following administration of Moderna COVID-19 Vaccine.

Monitor Moderna COVID-19 Vaccine recipients for the occurrence of immediate adverse reactions according to the Centers for Disease Control and Prevention (CDC) guidelines (https://www.cdc.gov/vaccines/covid-19/clinical-consideration...).

5.2 Myocarditis and Pericarditis

Postmarketing data with authorized or approved mRNA COVID-19 vaccines demonstrate increased risks of myocarditis and pericarditis, particularly within the first week following vaccination. For Moderna COVID-19 Vaccine, the observed risk is highest in males 18 years through 24 years of age. Although some cases required intensive care support, available data from short-term follow-up suggest that most individuals have had resolution of symptoms with conservative management. Information is not yet available about potential long-term sequelae.

The CDC has published considerations related to myocarditis and pericarditis after vaccination, including for vaccination of individuals with a history of myocarditis or pericarditis (https://www.cdc.gov/vaccines/covid-19/clinical-consideration...).

5.3 Syncope

Syncope (fainting) may occur in association with administration of injectable vaccines. Procedures should be in place to avoid injury from fainting.

5.4 Altered Immunocompetence

Immunocompromised persons, including individuals receiving immunosuppressive therapy, may have a diminished response to Moderna COVID-19 Vaccine.

5.5 Limitations of Vaccine Effectiveness

Moderna COVID-19 Vaccine may not protect all vaccine recipients.


Those last two points are why it is was the right thing to do for ostensibly healthy people to get vaccinated.

Because there are people we know it doesn't work for and people we don't know it doesn't work for.


How did that make it "the right thing to do" for healthy people to take the COVID shots? Given their extremely poor effectiveness against transmission, the odds of the groups in those last two points eventually being infected with SARS-CoV-2 were no different with vaccine uptake at 60% or 90% or 99%. What, then, is accomplished by forcing healthy adolescents (for example) to take these shots?


I lost track of COVID research in the past two years. Can you please provide me some good articles about bad transmission effectiveness? I’ve seen this mentioned many times here, but my search seems contradict to that: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10073587/


Conflicting papers have been published on transmission effectiveness. Everyone believes whatever they want.

“Similarly, researchers in California observed no major differences between vaccinated and unvaccinated individuals in terms of SARS-CoV-2 viral loads in the nasopharynx, even in those with proven asymptomatic infection.

Thus, the current evidence suggests that current mandatory vaccination policies might need to be reconsidered, and that vaccination status should not replace mitigation practices such as mask wearing, physical distancing, and contact-tracing investigations, even within highly vaccinated populations.”

https://www.thelancet.com/journals/laninf/article/PIIS1473-3...


I thought that we had some new hard evidence, or revelation. So does this mean we still don’t know, or is there a considerable skew to one side in the statistical meaning, like in the case of eating red meat, or climate change, but as with everything there are contradicting studies?


I like to look at the big numbers when it comes to the effectiveness of measures. To me they tell the story. But that requires a lot of work, so I can’t really recommend diving into it.


None of the studies showing some level of effectiveness against transmission/infection show anything close to what would be necessary to establish herd immunity and thus provide durable protection against eventual infection for those who can't be vaccinated.


Do you have any recommendations of your own that you can share?


Sure. IMO it is important to have an overall picture of the fields of Concurrent/Parallel/Distributed architecture/programming before delving into the details of a language/library implementation. To that end i have found the following books useful;

1) Foundations of Multithreaded, Parallel, and Distributed Programming by Gregory R. Andrews - This is one of my favourites even though old. You get to learn/compare the different paradigms in one single book.

2) Parallel Programming: Concepts and Practice by Bertil Schmidt et al. - This is a more recent book with good explanations/coverage including CUDA.

3) The Art of Multiprocessor Programming by Maurice Herlihy et al. - Well known classic though with a main focus on shared-memory architectures.

Along with the above you also need more detailed language/library specific implementation books;

a) C++ Concurrency in Action by Anthony Williams.

b) Programming with POSIX Threads by David Butenhof.

c) UNIX Systems Programming: Communication, Concurrency and Threads by Kay Robbins and Steve Robbins.

Finally; for studying concurrency at the OS level where software meets hardware, i have found nothing better than;

i) Unix Systems for Modern Architectures: Symmetric Multiprocessing and Caching for Kernel Programmers by Curt Schimmel.


There have been a few minor revisions of some of the optional add on boards and things like SNAC adaptors for using original controllers from different systems.

There have also been a few different takes on making a mister in more of a console form factor, and boards that integrate into arcade cabinets or fit in ITX PC cases.

The software has come a hell of a long way. In the army days, the most advanced cores were 8 bit systems like the NES. Now we’ve got PlayStation 1, Sega Saturn and N64 in the works. Similar progress has been made supporting old computer and arcade systems too.

There is an upcoming sort of successor called Marsfpga that’s recently started being teased. From the little that’s been shared so far, the community seems hopeful that this will mean the Dreamcast and support for arcade games through the early 2000s are possibilities.

Once you get much beyond that era, an FPGA-based approach makes less sense - the systems become much, much more complex and also largely standardise around with x86 or ARM where there are always to run them without emulation at all. A notable exception to that is the PS3 with its cell architecture. Then again, people said for a long time that PS1 and Saturn were not possible.


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