Senescence is a biological, not oxidative or thermodynamic, phenomenon.
More oxidation, more metabolism, and more turnover gives you more chances to break down/accumulate mutations/shorten telomers, but that’s an artefact of cells running out of their means for rapid growth. These can be modified. Look, for example, at the countless immortalized cell cultures.
It is a biological problem with roots in statistical and biomolecular physics, like literally everything else in biology.
More oxidation, more metabolism, and more turnover gives you more chances to break down/accumulate mutations/shorten telomers, but that’s an artefact of cells running out of their means for rapid growth. These can be modified. Look, for example, at the countless immortalized cell cultures.
It is a biological problem with roots in statistical and biomolecular physics, like literally everything else in biology.