> Not sure how much difference this makes over the long run
I tune in all fourths as well. For me it has made a huge difference since I made the jump some years ago. Putting voicings, patterns, etc., into muscular memory is faster and a lot less work. For my purposes, it makes the instrument more intuitive with a better ear-hand connection. Even very advanced players trip on the G-B strings oddity (with things like playing a fast, angular melody on different string sets, without preparation, for example).
It's really nice to play a scale, come to the octave, slide, and keep on playing the same shape across the higher strings. It's made the fretboard feel a lot more transparent to me.
I tune in all fourths as well. For me it has made a huge difference since I made the jump some years ago. Putting voicings, patterns, etc., into muscular memory is faster and a lot less work. For my purposes, it makes the instrument more intuitive with a better ear-hand connection. Even very advanced players trip on the G-B strings oddity (with things like playing a fast, angular melody on different string sets, without preparation, for example).