Except for some niche Janko-layout keyboards like the WholeTone Revolution and Lumatone, isomorphic pianos haven't every really caught on. However, isomorphic layouts are very common on accordions! I have a chromatic button accordion at home and credit it with making music theory finally "click" for me. On my fiddle I can play in keys of G,D,A (and the relative minors) quite easily but struggle on weirder keys and can't handle chords at all. On the accordion it couldn't be easier!
I've had a few chromatic button accordions but never got gud. The layout is a delight to me... you can freeze your fingers in some position that sounds good and then just scoot it around and it sounds great anywhere. Such a cool instrument. Unfortunately, I have a fairly well-damaged right shoulder from RA and just wearing the damned things was too much for me. Maybe in another lifetime I'll learn that solo from "Cold Cold Ground." (which I think was on a diatonic, but whatever)
