Just anecdata, but the few things I use via Wine have all worked fine. I use yabridge so I can use windows VSTs in my Linux DAW.
Games (if they don't use kernel level anti cheat systems) are all flawless with Proton.
But, I honestly don't have a need to use much other windows only software. Almost everything I need to use has Linux versions, or alternatives that fit my needs.
I still have problems running some VSTs with yabridge (could be fixed in an afternoon, but it's important that people should know that it's not a plug and play experience).
Games (if they don't use kernel level anti cheat systems) are all flawless with Proton.
But, I honestly don't have a need to use much other windows only software. Almost everything I need to use has Linux versions, or alternatives that fit my needs.