There are a few broad reasons this can happen. One possibility is that they want to know if the treatment causes suicidal ideation, and the effect is often small enough that people more likely to report those symptoms independent of the treatment confound the result. Another is that they don't want to have to deal with the safety protocols that come with screening in participants who have reported any history of suicidality. Another still is that higher likelihood of an active mental health crisis means that it's harder for study coordinators to determine if participants have provided informed consent.

Sometimes studies are specifically for treatment-resistant depression, and I expect those studies are more likely to screen in participants with a history of suicidality, so I would recommend keeping an eye out for those if you would like to participate in clinical trials.

Be strong, brother, there is hope. Antidepressant can be really hard to administer, they exclude particularly vulnerable people from trials because they need to be protected the most.

May be you should try to contact people at metabolic mind (not for profit), they seem to be closely related to some treatment resistant depression trials.

They have a youtube channel with interview of researchers in the field.

This is only because society doesn't bear the cost of the natural outcome. If someone with suicidal ideation is excluded from trials on moral grounds and ultimately satisfies those internal cravings, nobody is at fault.

> This is only because society doesn't bear the cost of the natural outcome

Society doesn't bear the cost of someone killing themselves? That can't be what this means, but it's hard for me to read it a different way.

> If someone with suicidal ideation is excluded from trials on moral grounds and ultimately satisfies those internal cravings, nobody is at fault.

If someone with suicidal ideation is included in trials where drugs may INCREASE those ideations and they kill themselves, then the trial is at fault. You're not actually contending that they should be included anyway because they'll probably kill themselves anyway?

On the flip side, the drugs may have decreased the ideations. The entire point of it being a trial is that it's unknown.

I can think of someone who might be at fault.

Then why don't you tell the room who it is?

The type of depression that makes the sufferer lie about not having suicidal ideations

Or the type of depression that doesn't lead to suicide ideation because depression, in and of itself, is an incredibly broad term and not everyone that is depressed wants to die.

The type of person who doesn't have suicidal ideations are on the low end of the pool. They are the type of depressed people that things like hanging around friends, going outside, or eating a diet that's not poo works on.